Cav1-KO

모델명

C57BL/6Smoc-Cav1em1Smoc

카탈로그

NM-KO-190930

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Cav1

Synonyms

Cav; Cav-1

NCBI ID

12389

MGI ID

102709

Ensembl ID

ENSMUSG00000007655

Pubmed

Cav1

Human Ortholog

CAV1

모델 설명

Exon 3 of Cav1 gene was deleted to generate Cav1 knockout mice.
신청분야：Tumor suppression,vascular system,fibrosis,Berardinelli-Seip congenital lipodystrophy

Disease Connection

Alzheimer's Disease

Phenotype(s)

MGI:5014041

Reference(s)

Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH, Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010;5(12):e15697

Breast Cancer

Phenotype(s)

MGI:3843497

Reference(s)

Mercier I, Casimiro MC, Zhou J, Wang C, Plymire C, Bryant KG, Daumer KM, Sotgia F, Bonuccelli G, Witkiewicz AK, Lin J, Tran TH, Milliman J, Frank PG, Jasmin JF, Rui H, Pestell RG, Lisanti MP, Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. Am J Pathol. 2009 Apr;174(4):1172-90

Hypertrophic Cardiomyopathy

Phenotype(s)

MGI:2669401

Reference(s)

Park DS, Cohen AW, Frank PG, Razani B, Lee H, Williams TM, Chandra M, Shirani J, De Souza AP, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP, Caveolin-1 Null (-/-) Mice Show Dramatic Reductions in Life Span. Biochemistry. 2003 Dec 30;42(51):15124-15131

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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