Cdk4-KO
모델명
C57BL/6Smoc-Cdk4em1Smoc
카탈로그
NM-KO-190614
모델 상태
Developing
유전자 요약
Official Symbol
Cdk4
모델 설명
Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice.
신청분야：The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).
*Literature published using this strain should indicate: Cdk4-KO mice (Cat. NO. NM-KO-190614) were purchased from Shanghai Model Organisms Center, Inc..
Disease Connection
Type 1 Diabetes Mellitus
당신은 또한 좋아할 수 있습니다
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회
Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회