Atp4b-IRES-CreERT2

모델명

C57BL/6Smoc-Atp4bem1(IRES-CreERT2-WPRE-pA)Smoc

카탈로그

NM-KI-210118

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Atp4b

Synonyms

AV080843

NCBI ID

11945

MGI ID

88114

Ensembl ID

ENSMUSG00000031449

Pubmed

Atp4b

Human Ortholog

ATP4B

모델 설명

An IRES-CreERT2-WPRE-pA expression cassette was knocked into the Atp4b gene start codon site.Besides,An IRES-CreERT2 expression cassette were knock into the Bhlha15 gene stop codon site to generate Atp4b-IRES-CreERT2(2)(Stock No. NM-KI-210119) mice.
신청분야：Cre tool mice

검증 데이터

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Fig1. CreERT2-mediated recombination in the stomach of Atp4bCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the stomach of Atp4bCreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. Some leakiness was detected prior to tamoxifen exposure.

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Fig2. Detection of tdTomato (red) in various tissues of  Atp4bCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the glandular stomach. Tdtomato can also be detected in the pituitary, thymus, salivary glands, brown adipose tissue, spleen, pancreas, and muscle. Some leakiness was detected prior to tamoxifen exposure. TdTomato expression can not be detected in the brain, liver, lung, large intestine, small intestine, kidney or skin.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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