Lrat-2A-Cre
모델명
C57BL/6Smoc-Lratem1(2A-Cre)Smoc
카탈로그
NM-KI-190097
모델 상태
Repository Live
유전자 요약
Official Symbol
Lrat
모델 설명
검증 데이터
Fig1. Expression Pattern of tdTomato in LratCre/+ ; Rosa26tdTomato/+ mice.
Cre mediated recombination in liver nonparenchymal cells of LratCre/+ ; Rosa26tdTomato/+ mice. This strain represents an effective tool for generating liver nonparenchymal cells specific targeted mutants.
Fig2. Validation of tdTomato expression by fluorescence assay.
The liver nonparenchymal cells of Lrat-Cre mice were detected by fluorescence.
Fig. 3 Detection of tdTomato(red) in various tissues of LratCre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the heart, liver, lung, stomach, uterus, colon, intestine, muscle and spleen. Tdtomato can not be detected in the retina, brown fat, submandibular gland or thymus. (For more detailed information please contact our technical advisor.)
간행물
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
References：Cell Metabolism
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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