Aqp5-Cre

모델명

C57BL/6Smoc-Aqp5em1(iCre-WPRE-polyA)Smoc

카탈로그

NM-KI-200062

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Aqp5

Synonyms

-

NCBI ID

11830

MGI ID

106215

Ensembl ID

ENSMUSG00000044217

Pubmed

Aqp5

Human Ortholog

AQP5

모델 설명

A iCre-WPRE-polyA expression cassette was knocked into the Aqp5 gene start codon site.
신청분야：Cre recombinase tool; Aquaporin 5 (AQP5) belongs to a family of water channel proteins that allow water to pass through the plasma membrane by osmosis. AQP5 is expressed in salivary gland and lung epithelial cells. When crossed with a reporter mice, reporter gene expression can be detected in Aqp5 positive cells. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

검증 데이터

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Fig. 1 Cre-mediated recombination in the lung of Aqp5Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the lung epithelial cells derived from Aqp5Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Aqp5Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in lung epithelial cells, salivary gland, pancreas, brain, stomach, large intestine and esophagus. TdTomato can also be detected in individual cells of the heart, kidney, spleen, ovary and uterus. (For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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