Gad2-IRES-Cre

모델명

C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc

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NM-KI-200078

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Gad2

모델 설명

A IRES-iCre-pA expression cassette was knocked into the Gad2 gene stop codon site.
신청분야:By mating the reporter mice with Cre-expressing mice, Gad2 positive cells derived from double-positive mice were permanently labeled by fluorescent protein. It can be used to trace Gad2-positive cells.

검증 데이터

Gad2-iCre-1.png

Fig. 1 Detection of tdTomato (red) in the retina of Gad2icre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination in the retinal ganglion cell layer (yellow arrow) and inner nuclear layer (red arrow) of Gad2iCre/+; Rosa26tdTomato/+ mouse. 

Gad2-iCre-2.png

Fig. 2 Detection of tdTomato (red) in some cells of the cortex and hippocampus drived from Gad2icre/+; Rosa26tdTomato/+ mice.

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Fig. 3 Detection of tdTomato (red) in various tissues of Gad2icre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination in some cells of the brain, pituitary gland, retina, lung, heart, liver, submandibular gland, brown fat, kidney, pancreas, intestine, colon,  epididymis, muscle, skin and thymus can be observed. Tdtomato can not be detected in the spleen and testis. (For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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