Slc17a6-IRES-Cre

모델명

C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc

카탈로그

NM-KI-200087

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Slc17a6

Synonyms

DNPI; VGLUT2; 2900073D12Rik

NCBI ID

140919

MGI ID

2156052

Ensembl ID

ENSMUSG00000030500

Pubmed

Slc17a6

Human Ortholog

SLC17A6

모델 설명

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.
신청분야：Cre recombinase tool; The glutamate transporter 2 gene (Vglut2/Slc17a6) is expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

검증 데이터

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Fig. 1 Cre-mediated recombination in the brain of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and thalamus derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the retina of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Slc17a6Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, striatum and thalamus. TdTomato can also be detected in individual cells of the retinal ganglion cell layer and extranet layer, pituitary gland, heart, kidney, testis, epididymis, brown fat, thymus, spleen, stomach, skeletal muscle, intestine, colon, salivary gland and pancreas islet. Tdtomato expression can not be observed in the lung, liver or skin. (For more detailed information please contact our technical advisor.)


간행물

Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus–thalamus circuitry
References：PNAS

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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