Calb2-IRES-Cre

모델명

C57BL/6Smoc-Calb2em1(IRES-iCre-SV40-pA)Smoc

카탈로그

NM-KI-200102

모델 상태

Repository Live

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유전자 요약

Official Symbol
Calb2

Synonyms

CR

NCBI ID

12308

MGI ID

101914

Ensembl ID

ENSMUSG00000003657

Pubmed

Calb2

Human Ortholog

CALB2

모델 설명

A IRES-iCre expression cassette was knocked into the Calb2 gene stop codon site. Calb2 gene encodes calbindin 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The protein plays a key role in the nervous system.
신청분야：Cre recombinase tool

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Fig. 1 Cre-mediated recombination in the pituitary gland of Calb2Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the hippocampus, cortex, olfactory bulb and cerebellar purkinje cells of Calb2Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of  Calb2Cre/+; Rosa26tdTomato/+ mice. Tdtomato expression can be detected in the brain, heart, lung, liver, stomach, kidney, pancreas, intestine, testis, epididymis, spleen, esophagus, thymus and colon.  (For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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