Etv1-CreERT2

모델명

C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc

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NM-KI-200105

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Etv1

Synonyms

ER81; Etsrp81

NCBI ID

14009

MGI ID

99254

Ensembl ID

ENSMUSG00000004151

Pubmed

Etv1

Human Ortholog

ETV1

모델 설명

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.
신청분야：Cre recombinase tool

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Etv1-(CreERT2)-1.png

Fig. 1 Detection of tdTomato (red) in the heart of Etv1CreERT2/+; Rosa26tdTomato/+  mouse. CreERT2-mediated recombination in some of the left atrium and right ventricle cells of Etv1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

Etv-creERT2-2.png

Fig. 2 Detection of tdTomato (red) in the retina of Etv1CreERT2/+; Rosa26tdTomato/+  mouse after tamoxifen treatment. CreERT2-mediated recombination in the retinal ganglion cell layer (green arrowhead) and inner nuclear layer (yellow arrowhead) of Etv1CreERT2/+; Rosa26tdTomato/+ mouse can be induced by tamoxifen. 

Etv1-(CreERT2)-3.png

Fig. 3 Detection of tdTomato (red) in various tissues of Etv1CreERT2/+; Rosa26tdTomato/+ mice. 

CreERT2-mediated recombination in the heart and retina can be induced by tamoxifen. And tdTomato expression can also be observed in the brain, lung, stomach, colon, intestine, kidney and pancreas, but not in liver.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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