Axin2-CreERT2

모델명

C57BL/6Smoc-Axin2em1(CreERT2-pA)Smoc

카탈로그

NM-KI-200109

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Axin2

Synonyms

Axi1; Axil; Conductin

NCBI ID

12006

MGI ID

1270862

Ensembl ID

ENSMUSG00000000142

Pubmed

Axin2

Human Ortholog

AXIN2

모델 설명

A CreERT2-pA expression cassette was knocked into the Axin2 gene start codon site. As Axin2 is an intracellular protein, it is essential for identifying a surface marker for stem cell purification. When these Axin2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Axin2 expressing cells.
신청분야：Cre recombinase tool; Signaling pathway; Stem cells

검증 데이터

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Fig. 1 CreERT2-mediated recombination in the villi and crypts of small Intestine of Prom1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.


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Fig. 2 CreERT2-mediated recombination in the alveoli of Axin2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.


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Fig.3 Tdtomato was also abundantly expressed in brain, large intestine, small intestine, kidney, liver, lung, ovary (leaky  expression), and uterus (leaky expression);  expressed in brown fat, eye, heart valve, muscle, pancreas, stomach and thymus (leaky expression). There was a small amount of expression in salivary glands and spleen.（For more information please contact: 400-728-0660.）


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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