Nos1-IRES-Cre

모델명

C57BL/6Smoc-Nos1em1(IRES-iCre)Smoc

카탈로그

NM-KI-200113

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Nos1

Synonyms

NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik

NCBI ID

18125

MGI ID

97360

Ensembl ID

ENSMUSG00000029361

Pubmed

Nos1

Human Ortholog

NOS1

모델 설명

A IRES-iCre expression cassette was knocked into the Nos1 gene stop codon site.
신청분야：Cre recombinase tool; NOS1, the neurogenic nitric oxide synthase, is a key enzyme responsible for the production of the signaling molecule nitric oxide (NO) by neurons. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying diseases with impaired or reduced nitric oxide release, such as achalasia of cardia, hirschsprung's disease, hypertrophic pyloric stenosis, etc.

검증 데이터

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Fig. 1 Cre-mediated recombination in the brain of Nos1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the olfactory bulb, cortex and hippocampus derived from Nos1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the large intestine of Nos1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscular layer and mucous layer of the wall of the large intestine derived from Nos1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Nos1Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in  the brain, eyes, pituitary gland, heart, liver, stomach, brown fat, kidney, pancreas, thymus, colon, spleen, skin, muscle, uterus, ovary and submandibular gland. (For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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