Isl1-Cre

모델명

C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc

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NM-KI-200126

모델 상태

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Isl1

모델 설명

A iCre-WPRE-pA expression cassette was knocked into the Isl1 gene start codon site.
신청분야:Cre recombinase tool; Isl1-Cre mice express Cre recombinase under the control of the ISL1 transcription factor. It can be used for lineage tracing of Isl1 positive cells.

검증 데이터

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Fig. 1 Cre-mediated recombination in the retina of IslCreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer (RGC) and inner nuclear layer (INL) of IslCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the pancreas of IslCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the acinar cells and islet cells derived from IslCre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of IslCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the retina, pancreas, heart, brain, pituitary gland, lung, liver, stomach, submandibular gland, brown fat, kidney, intestine, colon, spleen, thymus, testis and epididymis. (For more detailed information please contact our technical advisor.)



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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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