Gpr65-IRES-Cre

모델명

C57BL/6Smoc-Gpr65em1(IRES-iCre)Smoc

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NM-KI-200135

모델 상태

Embryo cryopreservation

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모델 설명

A IRES-iCre expression cassette was knocked into the Gpr65 gene stop codon site.
신청분야:Cre recombinase tool; The G-protein-coupled receptor(GPR65) neurons  innervate intestinal villi and gastric mucosa to sense nutrients. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

검증 데이터

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Fig. 1 Cre-mediated recombination in the intestine of Gpr65Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the large intestine and small intestine derived from Gpr65Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Gpr65Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the pituitary gland, heart, liver, lung, stomach, salivary gland, kidney, pancreas, large intestine, skin, testis and epididymis. TdTomato can also be detected in individual cells of the thymus and spleen. Tdtomato expression can not be observed in brown fat. (For more detailed information please contact our technical advisor.)



당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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