Il17a-Cre

모델명

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NM-KI-200137

모델 상태

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유전자 요약

Official Symbol
IL17A

Synonyms

Il17; Ctla8; IL-17; Ctla-8; IL-17A

NCBI ID

16171

MGI ID

107364

Ensembl ID

ENSMUSG00000025929

Pubmed

IL17A

Human Ortholog

IL17A

모델 설명

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.
신청분야：Cre recombinase tool; T helper cell

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Fig. 1 Cre-mediated recombination in the lung of IL17aCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in  pulmonary immune cells of IL17aCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of  IL17aCre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in   the lymph nodes of the intestine and colon. Tdtomato expression can also be observed in some cells of the thymus and in individual cells of lung, kidney and liver. (For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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