Tagln-Cre

모델명

C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc

카탈로그

NM-KI-200144

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol

모델 설명

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.
신청분야:Cre recombinase tool

검증 데이터

image.png

Fig. 1 Cre-mediated recombination in the embryo of TaglnCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the vessels of E11.5 TaglnCre/+; Rosa26tdTomato/+ mouse embryo.

image.png

Fig. 2 Cre-mediated recombination in the lung of TaglnCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary vascular smooth muscle cells of TaglnCre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 3 Detection of tdTomato(red) in various tissues of TaglnCre/+; Rosa26tdTomato/+ mice. Tdtomato was abundantly expressed in the brain, eyes, heart, liver, lung, muscle, pancreas, testis, epididymis, salivary gland, spleen and thymus. Tdtomato was also detected in some cells of the colon, intestine, kidney, skin and in individual cells of brown fat and stomach. (For more detailed information please contact our technical advisor.)



당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

조회