Myf5-Cre

모델명

C57BL/6Smoc-Myf5em1(Cre-WPRE-polyA)Smoc

카탈로그

NM-KI-200147

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Myf5

Synonyms

Myf-5; bHLHc2; B130010J22Rik

NCBI ID

17877

MGI ID

97252

Ensembl ID

ENSMUSG00000000435

Pubmed

Myf5

Human Ortholog

MYF5

모델 설명

A Cre-WPRE-polyA expression cassette was knocked into the Myf5 gene start codon site. Myogenic factor 5 (Myf5) belongs to the MRF family transcription factors that regulate myogenesis. It is expressed in the skeletal muscle and satellite cells. Severe loss of skeletal muscle following ablation of Myf5-expressing progenitors. This strain is useful in studying the differentiation of skeletal muscle.
신청분야：Cre recombinase tool

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Fig. 1 Cre-mediated recombination in the skeletal muscle of Myf5Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle cells of Myf5Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Myf5Cre/+; Rosa26tdTomato/+ mice. Tdtomato was expressed in the skeletal muscle. TdTomato can also be detected in individual cells of the brain, pituitary gland, eyes, salivary gland, heart, liver, spleen, lung, kidney, colon, intestine, stomach, pancreas, reproductive system and skin. (For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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