Il13-IRES-Cre

모델명

C57BL/6Smoc-Il13em1(IRES-iCre)Smoc

카탈로그

NM-KI-200166

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
IL13

모델 설명

A IRES-iCre expression cassette was knocked into the Il13 gene stop codon site. This gene encodes a multifunctional cytokine. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This cytokine participates in the regulation of immune response, inflammatory response and hematopoietic process.
신청분야:Cre recombinase tool; IL13-expressing cell

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Fig. 1 Cre-mediated recombination in the thymus of Il13Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in  individual cells of the thymus derived from Il13Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the spleen of Il13Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in  the spleen derived from Il13Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of  Il13Cre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the thymus and spleen and in individual cells of the stomach and testis. Tdtomato expression can not be observed in the heart. (For more detailed information please contact our technical advisor.)



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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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