Ace2-2A-CreERT2

모델명

C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc

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NM-KI-200187

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
ACE2

모델 설명

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.
신청분야:Cre recombinase tool

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Fig. 1 CreERT2-mediated recombination in the lung of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary bronchial epithelial cells of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

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Fig. 2 CreERT2-mediated recombination in the kidney of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the proximal tubule of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 



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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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