Myl2-Cre-IRES-EGFP

모델명

C57BL/6Smoc-Myl2em1(Cre-IRES-EGFP-WPRE-polyA)Smoc

카탈로그

NM-KI-200224

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Myl2

Synonyms

MLC-2; Mlc2v; Mylpc; MLC-2v; MLC-2s/v

NCBI ID

17906

MGI ID

97272

Ensembl ID

ENSMUSG00000013936

Pubmed

Myl2

Human Ortholog

MYL2

모델 설명

A Cre-IRES-EGFP-WPRE-polyA expression cassette was knocked into the Myl2 gene start codon site.
신청분야：These mice express cre recombinase from the Myl2 locus. This strain may be useful for studying cardiogenesis.

검증 데이터

NM-KI-200224 Myl2-Cre-IRES-EGFP-1.png

Fig.1 Cre-mediated recombination in the heart of Myl2Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the ventricular cardiomyocytes and few atrial cells of Myl2Cre/+; Rosa26tdTomato/+ mouse. EGFP(green) expression can not be observed.

NM-KI-200224 Myl2-Cre-IRES-EGFP-2.png

Fig. 2 Detection of tdTomato(red) and GFP(green) in various tissues of Myl2Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the heart, few cells of thymus, bronchus, submandibular gland, skin, kidney and choroid plexus of fourth ventricle. Tdtomato expression can not be observed in the brown fat, liver, stomach, intestine, colon, spleen, pancreas, testis and epididymis. EGFP expression can not be observed.(For more detailed information please contact our technical advisor.)

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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