Opn4-Cre

모델명

C57BL/6Smoc-Opn4em1(Cre-WPRE-polyA)Smoc

카탈로그

NM-KI-200304

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol
Opn4

모델 설명

Cre-WPRE-polyA expression cassette was knocked into the Opn4 gene start codon site. The melanopsin gene (Opn4) encodes a functional photopigment. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying circadian rhythm regulation.
신청분야:Cre recombinase tool; Circadian rhythm regulation

검증 데이터

image.png

Fig. 1 Cre-mediated recombination in the eyes of Opn4Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in retinal ganglion cell layer (RGC) and inner nuclear layer of Opn4Cre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 2 Detection of tdTomato(red) in various tissues of  Opn4Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in   the eyes, hippocampus, olfactory bulb, serous layer of the large intestine, testis, epididymis, pulmonary bronchial epithelial cells, kidney, thymus and pituitary gland. Tdtomato expression can not be observed in the cerebellum, heart, liver, spleen, muscle, skin, stomach, small intestine or submandibular gland. (For more detailed information please contact our technical advisor.)



당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

조회