Slco1c1-2A-CreERT2

모델명

C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc

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NM-KI-200262

모델 상태

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유전자 요약

Official Symbol
Slco1c1

Synonyms

Oatp2; Oatpf; OATP-F; OATP-14; Slc21a14

NCBI ID

58807

MGI ID

1889679

Ensembl ID

ENSMUSG00000030235

Pubmed

Slco1c1

Human Ortholog

SLCO1C1

모델 설명

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.
신청분야：Ischemic infarction

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Fig. 1 CreERT2-mediated recombination in the choroid plexus of Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 Labeling was also observed in the retina, muscles, but not in pituitary, heart, lungs, stomach, submandibular gland, brown fat, kidney, pancreas, small and large intestine, spleen, skin, ovaries and uterus.（For more information please contact: 400-728-0660.）

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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