Chga-CreERT2

모델명

C57BL/6Smoc-Chgaem(CreERT2-Wpre-pA)Smoc

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NM-KI-204993

모델 상태

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유전자 요약

Official Symbol
Chga

Synonyms

cgA， ChrA

NCBI ID

12652

MGI ID

88394

Ensembl ID

ENSMUSG00000021194

Pubmed

Chga

Human Ortholog

CHGA

모델 설명

CreERT2-Wpre-pA expression cassette was knocked into the Chga gene.
신청분야：By mating the reporter mice with CreERT2-expressing mice, Chga positive cells derived from double-positive mice were permanently labeled by fluorescent protein after tamoxifen treatment. These mice may be useful in the research of hypertension, heart disease and enteritidis.

검증 데이터

Chga-CreERT2-1.png

Fig. 1 Detection of tdTomato (red) in the pancreas of ChgaCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the pancreas islet and some acinar cells can be induced by tamoxifen. 

Chga-CreERT2-3.png

Fig. 2 Detection of tdTomato (red) in various tissues of ChgaCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in some cells of the pancreas, lung, kidney and submandibular gland can be induced by tamoxifen. Some leakiness were detected in the brain, stomach, colon and intestine prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the liver, brown fat, spleen, muscle, skin, testis and epididymis. (For more detailed information please contact our technical advisor.)

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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