Sox9-IRES-CreERT2

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C57BL/6Smoc-Sox9em(IRES-CreERT2-SV40pA)Smoc

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NM-KI-204996

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Official Symbol
Sox9

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IRES-CreERT2-SV40pA expression cassette was knocked into the Sox9 gene .
신청분야:These mice may be used to generate tamoxifen-induced conditional mutations for studying gain-or-loss of function and/or fate mapping related to Sox9 expression during stem cell differentiation.

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Fig. 1 CreERT2-mediated recombination in the heart of Sox9CreERT2/+;R26tdtomato/+ mouse. TdTomato can be detected in the heart of Sox9CreERT2/+;R26tdtomato/+ mouse. (Documented in the following reference.)

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Fig. 2 CreERT2-mediated recombination in the heart of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in some cells of ventricle and atria derived from Sox9CreERT2 /+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

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Fig. 3 CreERT2-mediated recombination in the hair follicles of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the hair follicles and epidermis derived from Sox9CreERT2 /+; Rosa26tdTomato/+ mouse.

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Fig. 4 CreERT2-mediated recombination in the liver of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the liver of Sox9CreERT2 /+; Rosa26tdTomato/+ mouse.

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Fig. 5 Detection of tdTomato(red) in various tissues of Sox9CreERT2/+; Rosa26tdTomato/+ mice. CreERT2 mediated recombination can be detected in the heart, hair follicles and epidermis. Tdtomato expression can be also detected in individual cells derived from liver, brain, pituitary gland, retina, stomach, large intestine, small intestine, lung, submandibular gland, kidney, pancreas, spleen, thymus and ovary, except for brown fat tissue and muscle. (For more detailed information please contact our technical advisor.)




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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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