CAG-hACE2-IRES-Luc-Tg

모델명

C57BL/6Smoc-Tgtn(CAG-human ACE2-IRES-Luciferase-WPRE-polyA)Smoc

카탈로그

NM-TG-200002

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol

모델 설명

The transgene is composed of a CAG-human ACE2-IRES-Luciferase-WPRE-polyA expression cassette under the control of CAG promter.
신청분야:corona virus related research

검증 데이터

ACE2-HU.png

Figure 1. Luciferase expression of the CAG-hACE2-IRES-Luciferase transgenic mice.

ACE2-HU-wb-EN.jpg

Figure 2. Western blot analysis of  ACE2  protein from the CAG-hACE2-IRES-Luciferase transgenic mice. 

ace2-3.png

Figure 3. Virus titers in the lungs of hACE2 Tg mice after SARS-CoV-2 infection. Groups of hACE2 Tg mice and wild type mice were inoculated with the same dose of SARS-CoV-2, the result shows that hACE2 Tg mice were highly susceptible to SARS-CoV-2 infection.

image.png

Figure 4. Body weight change in hACE2 Tg mice after drug treatment.

image.png

Figure 5. The viral load in the lung tissues of hACE2 Tg mice after drug treatment. 



당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

조회