M-SRG

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SD-Rag2em1SmocIl2rgem1Smoc

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NR-KO-210360

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Exon 2-7of IL2rg gene in Rag2-KO(SD) rat were deleted to generate Rag2 and IL2rg knockout rat.

검증 데이터

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Fig1. Complete deletion of T, B and NK cells of M-SRG rats. Spleen and peripheral blood cells from SD and M-SRG rats were collected to analyze their compositions of T, B and NK cells by FACS.

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Fig2. Subcutaneous xenograft tumor growth of HT29 cells in M-SRG rats.  Human colorectal adenocarcinoma cell line HT-29 (2x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change.

image.pngFig3. Subcutaneous xenograft tumor growth of PC-3 cells in M-SRG rats. Human prostatic adenocarcinoma cell line PC-3 (2x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change.

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Fig4. Subcutaneous xenograft tumor growth of LNCaP clone FGC cells in M-SRG rats. Human metastatic prostate carcinoma cell line LNCaP clone FGC (2x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change. 

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Fig5. Subcutaneous xenograft tumor growth of A2780 cells in M-SRG rats.  Human ovarian cancer cell line HT-29 (1x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change. 

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Fig6. Subcutaneous xenograft tumor growth of MV4-11 cells in M-SRG rats. Human monocytic leukemia cell line MV4-11 (1x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change. 

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Fig7. Subcutaneous xenograft tumor growth of OCI-AML-3 cells in M-SRG rats.  Human acute myeloid leukemia cell line OCI-AML-3 (1x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A) Tumor volume. (B) Body weight change.

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Fig8. Blood Routine Tests in M-SRG rats.  

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Fig9. Blood biochemistry in M-SRG rats. 



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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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