BALB/c Nude
모델명
BALB/cAnSmoc-Foxn1nu/Smoc
카탈로그
SM-014
모델 상태
Repository Live
유전자 요약
Official Symbol
Foxn1
모델 설명
This strain carries a Foxn1nu mutation on the BALB/c background which will lead to T cell deletion. At the same time, the response to thymus-dependent antigens is limited, resulting in impaired B cell function while NK cells, macrophages, and antigen-presenting cells function normally. The complement activity is normal as well. Hair dysplasia causes aberrant hair growth in which the majority of the hair cannot protrude from the surface, resulting in a naked mouse phenotype.
검증 데이터
Fig1. Body weight growth curve of BALB/c Nude (n=30)
Fig2. Complete deletion of T, B cells of BALB/c Nude.
Fig3. Subcutaneous xenograft tumor growth in BALB/c Nude.
Fig4. Blood routine tests in BALB/c Nude.
Fig5. Blood biochemistry in BALB/c Nude.
Table 1. BALB/c Nude xenograft cell lines
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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