Cd8a-IRES-DTRGFP
모델명
C57BL/6Smoc-Cd8aem2(IRES-DTREGFP)Smoc
카탈로그
NM-KI-190045
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
Cd8a
모델 설명
검증 데이터
EGFP expression
Fig1. Validation EGFP expression in PBMC by FACS.(Cooperation with CrownBio)
Validation data of DTR function
Heterozygous CD8a-IRES-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. After the tumors grew to 100 mm3, the CD8a-IRES-DTRGFP mice were injected with Diphtheria toxin.
Fig2. The growth of MC38 tumors in Heterozygous CD8a-IRES-DTRGFP mice and C57BL/6 mice. (Cooperation with CrownBio)
Fig3. The percent of CD8+ T cell in peripheral blood of MC38 tumor-bearing CD8a-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. (Cooperation with CrownBio)
Fig4. The percent of CD8+ T cell in peripheral blood of MC38 tumor-bearing CD8a-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. Nearly complete depletion was achieved only after 1 dose administration of DT and the depletion effect lasted to day 14.(Cooperation with CrownBio)
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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