Foxp3-IRES-DTRGFP

모델명

C57BL/6Smoc-Foxp3em3(IRES-DTREGFP)Smoc

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NM-KI-190046

모델 상태

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유전자 요약

Official Symbol
Foxp3

모델 설명

A IRES-DTREGFP expression cassette was knocked into the Foxp3 gene stop codon site.
신청분야:DTR mouse

검증 데이터

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Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IRES-DTRGFP KI mice. 

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Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT).

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Fig3. The percent of  Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

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Fig4. The percent of  Treg+ and other immune cells in spleen and tumor of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

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Fig5.  The growth of MC38 tumors in Foxp3-IRES-DTRGFP mice and C57BL/6 mice. (In collaboration with CrownBio) 


당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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