Foxp3-IRES-DTR-2A-tdTomato(BALB/c)
모델명
BALB/cAnSmoc-Foxp3em9(IRES-DTR-2A-tdTomato)Smoc
카탈로그
NM-KI-200213
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
Foxp3
모델 설명
검증 데이터
CT 26 tumor cells were injected into FOXP3-DTR mice administered with different treatment, and Balb/c mice, respectively. And tumor growth curves of each group were recorded.
Fig 1. The growth of CT26 tumors in Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice. (In collaboration with CrownBio)
Proportion of different type-specific T cells and macrophages in peripheral blood of each group analyzed using FACS
Fig 2. The percentage of different type-specific T cells and macrophages in peripheral blood of CT26 tumor-bearing Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice is detected by FACS. (In collaboration with CrownBio)
Proportion of different type-specific T cells and macrophages in spleen and tumor of each group analyzed using FACS
Fig 3. The percentage of different type-specific T cells and macrophages in spleen and tumor of of CT26 tumor-bearing Foxp3-IRES-DTR-2A-tdTomato mice administered with different treatment and Balb/c mice is detected by FACS. (In collaboration with CrownBio)
Fig 4. DTR mediated cell knockout in spleen of Foxp3-DTR/tdTomato mice (BALB/c).
Fig 5. DTR mediated cell knockout in mesenteric lymph nodes of Foxp3-DTR/tdTomato mice(BALB/c).
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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