hACE2
모델명
C57BL/6Smoc-Ace2em3(hACE2-flag-Wpre-pA)Smoc
카탈로그
NM-HU-200218
모델 상태
Repository Live
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Official Symbol
ACE2
모델 설명
검증 데이터
Fig1. Analysis of ACE2 expression profile by qPCR in the ACE2 humanized mice. The homozygous and heterozygous KI mice express human ACE2 in lung, kidney and small intestine; while the heterozygous KI mice and wild type express mouse Ace2 on heart, lung, kidney and small intestine.
Fig2. Analysis of ACE2 gene expression in the lungs by RT-PCR in WT and ACE2 humanized mice. Mouse Ace2 mRNA was detectable by P7/8(446bp), human ACE2 mRNA was detectable by P5/6(283bp), M:100bp Plus DNA ladder from Transgen (BM311). The homozygous KI mouse expresses human ACE2 in the lungs, while the heterozygous KI mouse expresses both human ACE2 and mouse Ace2.
간행물
The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice
References：International Journal of Molecular Sciences
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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