hLRRC32

모델명

C57BL/6JSmo-Lrrc32tm(hLRRC32)Smoc

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NM-HU-220498

모델 상태

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유전자 요약

Gene Symbol
Lrrc32

모델 설명

The endogenous mouse Lrrc32 gene was replaced by human LRRC32 gene.

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Fig.1 Detection of LRRC32 expression on platelets and Treg cells from WT C57BL/6 and HO hLRRC32 mice in the resting state. (male, 21 weeks old)

The results show that in the resting state, platelets from homozygous hLRRC32 mice highly express hLRRC32, and Tregs highly express hLRRC32; platelets from WT mice highly express mLRRC32, while Tregs barely express mLRRC32.

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Fig.2 Detection of LRRC32 expression on Treg cells from WT C57BL/6 and HO hLRRC32 mice after stimulation.  (male, 21 weeks old)

The results show that after stimulating sorted CD4+ T cells, Tregs from homozygous hLRRC32 mice highly express hLRRC32, while Tregs from WT mice highly express mLRRC32.


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