hANGPTL3(5)

모델명

C57BL/6JSmo-Angptl3tm3(hANGPTL3)Smoc

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NM-HU-230047

모델 상태

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유전자 요약

Gene Symbol
Angptl3

모델 설명

The endogenous mouse Angptl3 gene was replaced by human ANGPTL3 gene.

검증 데이터

image.png

Fig.1 Detection of ANGPTL3 expression in liver of HO hANGPTL3(5) mice by RT-PCR. (male, 8wks)

Wild type: only one band at 155 bp with primers F1/R1(mAngptl3);

Homozygous: only one band at 155 bp with primers F2/R2(hANGPTL3).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human ANGPTL3 expression in serum by ELISA (n=3). 

Abbr.  HO, homozygous; WT, wild type; N.D. not detected.

image.png

Table.1 Blood biochemical test of WT mice and hANGPTL3(5) knockin mice. 

Values are expressed as mean±SEM.

Abbr. HO, homozygous; WT, wild type.


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