hSIGLEC15

모델명

C57BL/6JSmo-Siglec15tm1(hSIGLEC15)Smoc

카탈로그

NM-HU-190037

모델 상태

Embryo cryopreservation

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유전자 요약

Gene Symbol
SIGLEC15

모델 설명

The endogenous mouse Siglec15 gene was replaced by human SIGLEC15 gene.
신청분야:Immunotherapy,cancer research,drug screening

검증 데이터

SIGLEC15-HU-1.png

SIGLEC15-HU-2.png

Fig1. In vivo validation of humanized SIGLEC15 mice. Humanized SIGLEC15 mice were inoculated with MC38 colon cancer cells, and were randomly assigned into different groups  when the tumors grew to a volume of 100 mm3. Human-specifc, SIGLEC15 antibody ( 5G12-hIgG1 ) was given twice a week (BIW) for two weeks (In collaboration with Crownbio).  


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