Myl1-NLS-Cre

모델명

C57BL/6Smoc-Myl1em1(NLS-iCre-pA)Smoc

카탈로그

NM-KI-200124

모델 상태

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유전자 요약

Gene Symbol
Myl1

Synonyms

Mylf; MLC1f; MLC3f; AI325107

NCBI ID

17901

MGI ID

97269

Ensembl ID

ENSMUSG00000061816

Pubmed

Myl1

Human Ortholog

MYL1

모델 설명

A NLS-iCre-pA expression cassette was knocked into the Myl1 gene start codon site via CRISPR/Cas9 mediated recombination.
신청분야：Cre-mediated recombination can be detected in the skeletal muscle of Myl1-Cre  mice. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

검증 데이터

NM-KI-200124-Myl1-NLS-Cre-1.png

Fig. 1 Cre-mediated recombination in the skeletal muscle of Myl1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the skeletal muscle of Myl1Cre/+; Rosa26tdTomato/+ mouse. 

NM-KI-200124-Myl1-NLS-Cre-2.png

Fig. 2 Detection of tdTomato(red) in various tissues of Myl1Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the skeletal muscle. Tdtomato expression can also be detected in individual cells derived from liver, myocardium and brown fat. Tdtomato expression can not be observed in the brain and stomach. (For more detailed information please contact our technical advisor.)

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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