Tmem119-2A-CreERT2

모델명

C57BL/6Smoc-Tmem119em2(P2A-CreERT2)Smoc

카탈로그

NM-KI-200234

모델 상태

Repository Live

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유전자 요약

Gene Symbol
Tmem119

Synonyms

obif; AW208946; BC025600

NCBI ID

231633

MGI ID

2385228

Ensembl ID

ENSMUSG00000054675

Pubmed

Tmem119

Human Ortholog

TMEM119

모델 설명

A P2A-CreERT2 expression cassette was knocked into the Tmem119 gene stop codon site.
신청분야：Cre tool mice

검증 데이터

图片4-1.png

图片5.png图片6.png图片7.pngFig1. Tmem119-CreERT2 mice effectively recombine a conditional allele in microglia.

A-B. Confocal micrograph showing tdTomato expression in IBA-positive microglia upon tamoxifen administration , Absence of tdTomato expression in untreated animals. C-D, Representative immunostaining for  astrocytes (C, GFAP, green), and neurons (D, NeuN, green) in tdTomato-expressing microglia of Tmem119-CreERT2+/−; Rosa26 tdTomato+/− mice. 

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간행물

Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization
References：

Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function
References：Cell Reports

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