hPD-L1(E3-4)
모델명
C57BL/6Smoc-Cd274em2(hPD-L1)Smoc
카탈로그
NM-HU-190039
모델 상태
Embryo cryopreservation
유전자 요약
Gene Symbol
Cd274
모델 설명
검증 데이터
Fig1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis.
Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.
Fig3. Immunotype in blood in hPD-L1 mice.
Fig4. Immunotype in spleen in hPD-L1 mice.
Fig5. Immunotype in bone marrow in hPD-L1 mice.
Fig6. In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A) PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice. All quantitative data are represented as mean ± SEM.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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