hCD3EDG
모델명
C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Smoc
카탈로그
NM-HU-220120
모델 상태
Repository Live
모델 설명
검증 데이터
Fig.1 Detection of human CD3E,CD3D,CD3G on T cell surface in HO hCD3EDG mice.
Fig.2 Lymphocyte Lineage Characterization in Blood in Homozygous hCD3EDG Mice.
Fig.3 In vivo AICD and irAE Assessment of Bispecific T Cell Engager Antibodies in Homzygous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to evaluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody in vivo.
Fig.4 In Vivo Response with Bispecific T Cell Engager Antibodies in Homozygous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to eveluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody.
Fig.5 In vivo AICD and irAE Assessment of CD3 Bispecific Antibody in homozygous hCD3EDG Mice.
The anti-tumor response of anti-mPD-1 was evaluated in homozygous hCD3EDG mice bearing MC38 syngeneic tumor model.
Fig.6 In vivo AICD and irAE Assessment of CD3 Bispecific Antibody with Homozgyous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to eveluate the AICD and irAE of anti-CD3×EpCAM bispecific antibody at low and high dose levels in vivo.
Fig.7 In Vivo Response with Bispecific T Cell Engager Antibodies.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
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