Zap70-W163C(Balb/c)

모델명

BALB/cAnSmoc-Zap70em(W163C)Smoc

카탈로그

NM-KI-210366

모델 상태

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유전자 요약

Official Symbol
Zap70

Synonyms

Srk; mur; mrtle; ZAP-70

NCBI ID

22637

MGI ID

99613

Ensembl ID

ENSMUSG00000026117

Pubmed

Zap70

Human Ortholog

ZAP70

모델 설명

These mice carry a W163C mutation of Zap70 gene.
신청분야：Rheumatoid arthritis model， Ankylosing spondylit，SKG mouse arthritis modelis model

Disease Connection

Rheumatoid Arthritis

Phenotype(s)

MGI:3698734

Reference(s)

Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, Sakaguchi S, Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60

검증 데이터

image.pngFig1. Elicitation of chronic arthritis by administration of Mannan. 

Signs of arthritis were assessed by a visual score where 0=no joint swelling, 1=mild to moderate swelling, 2=substantial swelling of the wrist or ankle joint, and 3=severe swelling of the wrist or ankle joint.

간행물

A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
References：Journal of Nanobiotechnology

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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