Nos3-KO

모델명

C57BL/6Smoc-Nos3em1Smoc

카탈로그

NM-KO-18022

모델 상태

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유전자 요약

Official Symbol
Nos3

Synonyms

eNOS; Nos-3; ecNOS; 2310065A03Rik

NCBI ID

18127

MGI ID

97362

Ensembl ID

ENSMUSG00000028978

Pubmed

Nos3

Human Ortholog

NOS3

모델 설명

Exon10-11 of B2m gene were deleted to generate B2m knockout mice.

Disease Connection

Hypertrophic Cardiomyopathy

Phenotype(s)

MGI:4367213
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nos1-KO(NM-KO-2111954) mice.

Reference(s)

Barouch LA, Cappola TP, Harrison RW, Crone JK, Rodriguez ER, Burnett AL, Hare JM, Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. J Mol Cell Cardiol. 2003 Jun;35(6):637-44

Nephrogenic Diabetes Insipidus

Phenotype(s)

MGI:3789190
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nos1-KO(NM-KO-2111954) and Nos2-KO(NM-KO-18022) mice.

Reference(s)

Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N, Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10616-21

Essential Hypertension

Phenotype(s)

MGI:2174979

Reference(s)

Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC, Hypertension in mice lacking the gene for endothelial nitric oxide synthase [see comments]. Nature. 1995 Sep 21;377(6546):239-42

Persistent Fetal Circulation Syndrome

Phenotype(s)

MGI:3618597

Reference(s)

Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ, Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?. Circ Res. 2004 Apr 30;94(8):1115-23

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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