Ldlr-KO(2)

모델명

C57BL/6Smoc-Ldlrem1Smoc

카탈로그

NM-KO-210198

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Ldlr

Synonyms

Hlb301

NCBI ID

16835

MGI ID

96765

Ensembl ID

ENSMUSG00000032193

Pubmed

Ldlr

Human Ortholog

LDLR

모델 설명

Ldlr-KO(2) mice(Stock No.NM-KO-210198) carry a knockout allele derived from the targeted deletion of exon 4. While Ldlr-KO mice(Stock No.NM-KO-190559) carrying the exon 6-10 deletion.

Disease Connection

familial hypercholesterolemia

Phenotype(s)

MGI:3691620

Reference(s)

Jones C, Hammer RE, Li WP, Cohen JC, Hobbs HH, Herz J, Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem. 2003 Aug 1;278(31):29024-30

Fatty Liver Disease

Phenotype(s)

MGI:3611043

Reference(s)

Subramanian S, Goodspeed L, Wang S, Kim J, Zeng L, Ioannou GN, Haigh WG, Yeh MM, Kowdley KV, O'Brien KD, Pennathur S, Chait A, Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J Lipid Res. 2011 Sep;52(9):1626-35

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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