Sh2d1a-KO

모델명

C57BL/6Smoc-Sh2d1aem1Smoc

카탈로그

NM-KO-200730

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Sh2d1a

Synonyms

SAP， Gm686

NCBI ID

20400

MGI ID

1328352

Ensembl ID

ENSMUSG00000005696

Pubmed

Sh2d1a

Human Ortholog

SH2D1A

모델 설명

Exon 2 of Sh2d1a gene was deleted to generate Sh2d1a knockout mice.

Disease Connection

X-Linked Lymphoproliferative Syndrome 1

Phenotype(s)

MGI:3036915

Reference(s)

Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL, Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7449-54

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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