Foxl1-2A-CreERT2

모델명

C57BL/6Smoc-Foxl1em1(2A-CreERT2)Smoc

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NM-KI-00135

모델 상태

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Official Symbol
Foxl1

Synonyms

Fkh6; fkh-6; FREAC7

NCBI ID

14241

MGI ID

1347469

Ensembl ID

ENSMUSG00000097084

Pubmed

Foxl1

Human Ortholog

FOXL1

모델 설명

A 2A-CreERT2 coexpression cassette is inserted before the stop codon of mouse Foxl1 gene via homologous recombination to establish a Foxl1-CreERT2 recombinase tool stain. This strain can be used to knockout target gene inFoxl1+ cells after tamoxifen treatment when crossed with flox mice.

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NM-KI-00135 1.png

Fig 1. CreERT2-mediated recombination in small intestine of Foxl1CreERT2/+; Rosa26tdTomato/+ mice.

NM-KI-00135 2.png

Fig 2. Detection of tdTomato (red) in various tissues of Foxl1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: small intestine, colon， stomach,lung, kidney, ovary. A few cells expressed in brain, adrenal gland, muscle, thymus. Tissues that unexpressed include retina, liver, salivary glands, brown fat, pancreas, spleen, skin. (4.5-month old, female) (For more detailed information please contact our technical advisor.) 

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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