Penk-IRES-Cre

모델명

C57BL/6Smoc-Penkem1(IRES2-iCre)Smoc

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NM-KI-200088

모델 상태

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유전자 요약

Official Symbol
Penk

Synonyms

ENK; PPA; Penk1; AI326464

NCBI ID

18619

MGI ID

104629

Ensembl ID

ENSMUSG00000045573

Pubmed

Penk

Human Ortholog

PENK

모델 설명

A IRES2-iCre expression cassette was knocked into the Penk gene stop codon site.
신청분야：Penk gene encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The gene product is involved in regulating synaptic plasticity, a crucial neurochemical mechanism underlying learning and memory.

검증 데이터

NM-KI-200088 Penk-IRES-Cre-1.png

Fig. 1 Cre-mediated recombination in the brain of PenkCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of PenkCre/+; Rosa26tdTomato/+ mouse.

NM-KI-200088 Penk-IRES-Cre-2.png

Fig. 2 Detection of tdTomato(red) in various tissues of  PenkCre/+; Rosa26tdTomato/+ mice. Tdtomato is expressed throughout the brain. And cre-mediated recombination can be detected in some cells of the pituitary gland, kidney, intetstine, colon, retina, brown fat, testis, epididymis, salivary gland, stomach, thymus, lung, heart, liver and skin. (For more detailed information please contact our technical advisor.)

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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