Oxt-IRES-Cre

모델명

C57BL/6Smoc-Oxtem1(IRES-iCre)Smoc

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NM-KI-200090

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Oxt

모델 설명

A IRES-iCre expression cassette was knocked into the Oxt gene stop codon site.
신청분야:Cre recombinase tool; Oxt-IRES-Cre mice express Cre recombinase under the control of the endogenous oxytocin (Oxt) promoter. Cre recombinase is expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in neurons expressing oxytocin.

검증 데이터

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Fig. 1 Cre-mediated recombination in the brain of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the olfactory bulb, cortex, thalamus and cerebellum derived from OxtCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the eyes of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal inner nuclear layer and ganglion cell layer derived from OxtCre/+; Rosa26tdTomato/+ mouse. 

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Fig. 3 Detection of tdTomato(red) in various tissues of OxtCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, retina, pituitary gland, heart, lung, liver, salivary gland, brown fat, kidney, pancreas, intestine, colon, spleen, ovary, skeletal muscle, skin and thymus. (For more detailed information please contact our technical advisor.)



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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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