Notch1-CreERT2

모델명

C57BL/6Smoc-Notch1em1(CreERT2-2xpA)Smoc

카탈로그

NM-KI-200122

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Notch1

Synonyms

N1; Mis6; Tan1; lin-12; 9930111A19Rik

NCBI ID

18128

MGI ID

97363

Ensembl ID

ENSMUSG00000026923

Pubmed

Notch1

Human Ortholog

NOTCH1

모델 설명

A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells.
신청분야：Cre recombinase tool;

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Fig. 1 CreERT2-mediated recombination in individual cells of small intestinal derived from Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 CreERT2-mediated recombination in individual cells of liver derived from Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 3 Labeling was also observed in individual cells of the brain, heart, brown fat, salivary gland, lung, liver, stomach, kidney, pancreas, epidermis, colon, spleen, thymus and muscle.(For more information please contact: 400-728-0660.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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