Ntrk2-CreERT2

모델명

C57BL/6Smoc-Ntrk2em1(CreERT2-WPRE-polyA)Smoc

카탈로그

NM-KI-200146

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Ntrk2

Synonyms

Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB

NCBI ID

18212

MGI ID

97384

Ensembl ID

ENSMUSG00000055254

Pubmed

Ntrk2

Human Ortholog

NTRK2

모델 설명

A CreERT2-WPRE-polyA expression cassette was knocked into the Ntrk2 gene start codon site. Ntrk2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. When these Ntrk2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Ntrk2 expressing cells.
신청분야：Cre recombinase tool; Neuroscience

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Fig. 1 CreERT2-mediated recombination in the multiple brain regions of Ntrk2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 CreERT2-mediated recombination in individual cells in the lungs of Ntrk2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 3 Tdtomato was also abundantly expressed in brown fat, and expressed in thymus, salivary gland, spleen, large intestine, stomach and skin. There was a small amount of expression in kidney, and no expression in the heart, small intestine and muscle.（For more information please contact: 400-728-0660.）



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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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