Oprk1-2A-Cre

모델명

C57BL/6Smoc-Oprk1em1(2A-Cre)Smoc

카탈로그

NM-KI-200299

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Oprk1

Synonyms

KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

NCBI ID

18387

MGI ID

97439

Ensembl ID

ENSMUSG00000025905

Pubmed

Oprk1

Human Ortholog

OPRK1

모델 설명

2A-Cre expression cassette was knocked into the Oprk1 gene stop codon site. Oprk1 (opioid receptor, kappa 1) encodes opioid receptor which was expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.
신청분야：Cre recombinase tool; Neuroscience

검증 데이터

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Fig. 1 Cre-mediated recombination in the brain of Oprk1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of Oprk1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Oprk1Cre/+; Rosa26tdTomato/+ mice. Tdtomato was also expressed in some cells of the liver, stomach, intestine, colon, muscle, eyes, heart, spleen and lung. Tdtomato expression can not be observed in the salivary gland, brown fat and skin.(For more detailed information please contact our technical advisor.)


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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