R26-pAPOE-hCYP3A4(FVB)
모델명
FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
카탈로그
NM-KI-18032
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
Gt(ROSA)26Sor
모델 설명
This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.
신청분야:metabolism
*Literature published using this strain should indicate: R26-pAPOE-hCYP3A4(FVB) mice (Cat. NO. NM-KI-18032) were purchased from Shanghai Model Organisms Center, Inc..
당신은 또한 좋아할 수 있습니다
Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회
Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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