hC5AR1/C5AR2

모델명

C57BL/6Smoc-C5ar1tm1(hC5AR1)C5ar2tm1(hC5AR2)/Smoc

카탈로그

NM-HU-2000018

모델 상태

Repository Live

PDF 받기

유전자 요약

Official Symbol
C5AR1

Synonyms

C5aR; C5r1; Cd88; D7Msu1

NCBI ID

12273

MGI ID

88232

Ensembl ID

ENSMUSG00000049130

Pubmed

C5AR1

Human Ortholog

C5AR1

Official Symbol
C5AR2

Synonyms

C5L2; Gpr77; E030029A11Rik

NCBI ID

319430

MGI ID

2442013

Ensembl ID

ENSMUSG00000074361

Pubmed

C5AR2

Human Ortholog

C5AR2

모델 설명

The endogenous mouse C5ar1 and C5ar2 gene was replaced by human C5AR1 and hC5AR2 gene.
신청분야：Immunotherapy,drug screening

검증 데이터

image.png

Fig1. Detection of C5AR1 expression on myeloid cells in blood in homozygous hC5AR1 mice. 

image.png

Fig2. Detection of C5AR1 expression on myeloid cells in bone morrow in homozygous hC5AR1 mice. 

image.png

Fig3. Detection of hC5AR2 expression on myeloid cells in heterozygous hC5AR1/hC5AR2 mice. (Note: Anti-human C5L2 (C5AR2) antibody was cross-binding with mouse C5AR2)

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

조회