hVISTA
모델명
C57BL/6Smoc-Vsirem1(hVSIR)/Smoc
카탈로그
NM-HU-00118
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
Vsir
모델 설명
검증 데이터
Figure 1. Detection of VISTA expression in peripheral blood cells of humanized VISTA mice.
The expression of human VISTA was detected by FACS. The results showed that the active expression of human VISTA can be detected in both activated CD4+ and CD8+ T lymphocytes collected from humanized VISTA mice.
Figure 2. In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized VISTA mice.
Humanized VISTA mice were inoculated with MC38 colon cancer cells,the animals were randomly assigned into a control group and a treatment group (n=6). The drug was administered on days 0, 3, 7, 10, 14, and 17 respectively.The antibody showed significant tumor inhibition at the recommended dose(TGI: tumor growth inhibition, p < 0.01). (Cooperation with WuXi Biologics)
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회